Biomolecule delivery

Formation of cyclodextrin-DNA nanoparticles

Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery

Advances in biotechnology in the last decade have enabled the development of a multitude of tools based on biomolecules (nucleic acids and proteins) that improve the diagnosis and treatment of many diseases. However, its application requires the use of transport systems capable of delivering these biomolecules, safely and effectively, to their place of action. Our research in this field is based on using macrocyclic molecules (mainly cyclodextrins) to design and build new delivery systems that improve the characteristics of those currently available.

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Our biomolecule carrier designs are perfectly defined at the molecular level (they are not polymers or mixtures of substances) and have a high density of functional groups that allow their properties to be improved. It is possible to incorporate, very precisely, other molecules into these systems, allowing them to recognise specific cells, react to certain stimuli or even be controlled externally. Furthermore, by combining macrocycles with different properties, we can provide biomolecule transport systems with specific functionalities, designing systems whose performance is increasingly more precise, reliable and adaptable to the specific characteristics required by each application.